小型低リスク甲状腺がんの健康状態評価における一般人口とがん生存者の差異:横断分析
Kendyl Carlisle1, Rebecca Kowalski1, Aprill N Park2
1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
まとめ
一般的な集団では,甲状腺がんの生存者よりも,小胞性甲状腺微小がん (PTMC) の健康効果が低いと報告されています. これらの発見は,PTMC治療の決定における比較効果の研究において極めて重要です.
科学分野:
- 腫瘍学
- 健康 経済
- 患者による報告結果
背景:
- 乳頭甲状腺小がん (PTMC) は,低リスクの甲状腺がんである.
- PTMCではアクティブ・サーベイランスや 放射性アブレーションのような 侵襲性の少ない治療法がますます使用されています
- 医療のユーティリティは 共有された意思決定と 比較効果モデルに不可欠ですが 明確な人口調達が必要です
研究 の 目的:
- 一般集団のボランティア (GenPop) と甲状腺がんの生存者 (TCSurv) の間でPTMCの健康状態の有用性評価を比較する.
- 比較効果の研究とPTMC管理のための共同意思決定の情報提供
主な方法:
- 10つのPTMC健康状態の健康ユーティリティを引き出すために時間トレードオフタスクを使用しました.
- 参加者は70人のGenPopボランティアと72人の甲状腺がん生存者 (TCSurv) でした.
- 単変数および多変数線形回帰分析を行い,共変数に調整し,治療合併症のサブグループ分析を行った.
主要な成果:
- GenPopは,PTMCの10つの健康状態すべてにおいて,TCsurvよりも著しく低い健康ユーティリティを報告した.
- GenPop と TCSurv の間のユーティリティの違いは,多変量分析において統計的に有意であった (p=0. 01).
- 合併症のないシナリオと比較して,PTMCのシナリオでは,ヘルスケアユーティリティは低かった.
結論:
- 一般的な集団のボランティアは,甲状腺がんの生存者と比較して,PTMCの健康状態の低い健康ユーティリティを報告しています.
- これらの不一致は,PTMCの比較有効性研究で医療ユーティリティを使用する際に,医療経済学者や医療提供科学者が考慮する必要があります.
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