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Updated: Sep 10, 2025

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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統合失調症における周辺的酸化ストレスマーカー:アルジェリア患者における赤血球グルタチオン過酸化,プラズママロンディアルデヒド,微量元素比率からの洞察

Latefa Saidane1, Nouria Dennouni Medjati2, Yahia Harek3

  • 1Analytical Chemistry and Electrochemistry Laboratory, Department of Biology, University of Abou Bekr Belkaid, 13000, Tlemcen, Algeria. saidanelatefa@gmail.com.

Biological trace element research
|August 23, 2025
PubMed
まとめ

マロンディアルデヒド (MDA) のような酸化ストレスマーカーは上昇し,抗酸化酵素グルタチオン過酸化酵素 (GPX1) の活動は統合失調症患者で減少した. 微量元素の不均衡,特に銅/セレニウム比は統合失調症のリスクと関連していました.

キーワード:
Cu/Se比赤血球グルタチオン過酸化剤マロンディアルデヒド統合失調症トレースエレメント

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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