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転写因子TFAP2Aは,PRAME転写を活性化することによって,三重陰性乳がんの成長と転移を誘導し,フェロプトーシスを阻害する

Bei Pei1, Huiting Sun2, Lingyun Xu3

  • 1The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China.

Naunyn-Schmiedeberg's archives of pharmacology
|August 23, 2025
PubMed
まとめ

転写因子AP- 2α (TFAP2A) は,PRAMEを活性化し,フェロプトーシスを抑制することで,トリプルネガティブ乳がん (TNBC) の進行を促進します. TFAP2AとPRAMEをターゲットにすることで,TNBCの潜在的な治療戦略が提供されます.

キーワード:
フェロプトーシス侵入するPRAME についてTFAP2ATNBC について

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