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カイネート受容体研究の過去50年の進化をマッピング:傾向,ホットスポット,新興領域
Yunsheng Liu1,2, Rongde Zhong2, Yao-Xuan Li1
1Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, 518000, China.
Naunyn-Schmiedeberg's archives of pharmacology
|August 23, 2025
まとめ
この文献分析は,カイネート受容体 (KAR) 研究の50年をマッピングし,主要な傾向と課題を明らかにしています. 将来の方向は,サブユニット固有の薬と神経学的疾患の臨床翻訳に焦点を当てています.
科学分野:
- 神経科学
- 薬理学について
- 図書館情報
背景:
- カイナート受容体 (KAR) は,シナプス可塑性などの脳機能に関与する重要なイオノトロプ的グルタミン酸受容体である.
- KARの調節不良は,神経学的および精神疾患,特にと関連しています.
研究 の 目的:
- 1975年から2024年までのカイナート受容体 (KAR) 研究に関する包括的な文献分析を行う.
- 進化の地図を作成し,KARの研究の傾向,ホットスポット,新興領域を特定します.
- 将来の研究を導くために,グローバルな貢献と翻訳の可能性の概要を提供します.
主な方法:
- CiteSpace,VOSviewer,およびBibliometrixを使用したPubMed,Web of Science,およびScopusからの11,671の出版物のサイエントメトリック分析.
- 出版傾向,国/機関からの貢献,ジャーナルの影響,著者の生産性,キーワードの進化の分析
- 研究のホットスポットと時間的なシフトを特定するために,テーマ別クラスタリングと引用バスト分析を行います.
主要な成果:
- KARの研究は2000年代初頭にピークに達し,近年の安定化により分子クローンと分布研究によって推進された.
- 米国は生産性と影響においてトップであり,中国は2015年以降に著しい成長を示しています.
- 研究段階は,分子特性 (1995年−2005年),機能性/疾患研究 (2005年−2015年),先進技術 (2015年−2024年) を特定した.
結論:
- KAR調節剤の臨床翻訳と精神疾患におけるその役割を理解する上で重要な課題が残っています.
- 将来の研究は,サブユニット特有の薬剤設計,学際的なイノベーション,およびグローバルな協力を優先すべきです.
- この図鑑のロードマップは,KARの研究におけるダイナミックな進化,協力パターン,満たされていない翻訳的ニーズを強調しています.
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