関連する実験動画

Updated: Sep 10, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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miR-146bは,上皮成長因子受容体/成長因子β受容体のプロフィブロティック・フィードフォワードループを破壊し,肺線維細胞の増殖と分化を抑制する

Yan Xie1, Yapei Huang1, Venkatlaxmi Chettiar1

  • 1Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska.

The Journal of pharmacology and experimental therapeutics
|August 23, 2025
PubMed
まとめ

Idiopathic pulmonary fibrosis (IPF) は 繊維細胞が過剰に成長することを意味します. この研究では,miR- 146bのレベルを回復させることで,線維細胞の増殖と分化が抑制され,IPFの潜在的な治療戦略が提供されていることが判明しました.

キーワード:
皮質成長因子受容体肺線維芽細胞拡散と差別化変換成長因子 α と β1変換成長因子β受容体miR-146bについて

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Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition06:02

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Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

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