ペット用のパーソナライズド医薬品
Konstantina Chachlioutaki1, Christos Ritzoulis2, Dimitrios G Fatouros1
1Department of Pharmacy, Aristotle University of Thessaloniki 54124 Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece.
International journal of pharmaceutics
|August 23, 2025
まとめ
獣医はピーナッツバターを用いて 3Dプリントしたペット用薬を 作ることができます この革新的なアプローチは 個別化された獣医療法において 精密な投与と 味覚のよい投与を保証します
科学分野:
- 獣医学
- 医薬品科学
- 3Dプリント技術
背景:
- パーソナライズされた獣医療法の需要が増えるため,ペットに合わせた用量形態が必要になります.
- 重量調整された,おいしい,そして柔軟な製剤の限られた利用は,ラベル外の薬物使用と手作業による複製のリスクにつながります.
- 現行の慣行では,精密な用量と,獣医学におけるエキシピエントの毒性を避けるという課題があります.
研究 の 目的:
- セミソリッドエクストルーション (SSE) 3Dプリントを使用したオンデマンドの獣医用コンパウンドプラットフォームを開発する.
- 味覚の良い獣医用薬剤を作るのに,種の好みの薬剤兼容の補助剤としてピーナッツバターを活用する.
- 調節可能な投与量で,ペット用医薬品を製造する.
主な方法:
- 半固体エクストルーション (SSE) 3Dプリントをオンデマンドの獣医用コンパウンドに使用しています.
- ピーナッツバターを主成分として使って 粉強化マトリックスを作りました
- プレドニゾロン (PRE) をマトリックスに組み込み,調節可能な用量で噛むことができるユニットを作成します.
主要な成果:
- 堅固な挤出特性と優れた用量線形性 (R2 > 0.99) を有する,うまく印刷された噛み付くユニット.
- 薬剤の即時放出と,自発的な経口摂取に適した機械的性質を達成した.
- 印刷された成分の安定性が冷蔵状態で14日以上証明された.
結論:
- 拡張可能な3Dプリントプラットフォームを導入し,獣医薬学的ケアを改善しました.
- ペットに個別化された薬を投与するためのピーナッツバター製剤の使用を検証した.
- 慢性的な獣医治療の正確な,美味しい,そして柔軟な投与を提供するこの技術の可能性を強調しました.
さらに関連する動画
関連する概念動画
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
01:15Drug Dosage Regimen: Overview
3.8K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.8K
01:02Prescription, Nonprescription and Orphan Drugs
844
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
844
01:28Biopharmaceutics and Pharmacokinetics: Overview
2.5K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.5K
01:29Drug Delivery: Parenteral Route
831
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
831
01:14Model Approaches for Pharmacokinetic Data: Compartment Models
198
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Two primary types of compartment models are recognized: mammillary and catenary. The more...
198