癌の生存者における無助妊娠率と結果:体系的なレビュー
Nivedita R Potapragada1, Molly Beestrum2, Kara N Goldman1
1Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Fertility and sterility
|August 23, 2025
まとめ
癌の生存者の無助妊娠は 生児の出生率が低くなります 特に放射線治療などの治療の後です 育児保全に関するカウンセリングは 将来の育児に関する情報に基づいた意思決定に不可欠です
科学分野:
- 生殖医学
- 腫瘍学
- 妊婦と胎児の医療
背景:
- 癌の生存者は 生殖能力と妊娠に関して 独特の課題に直面します
- 以前の研究では,この集団における無助妊娠の結果について,明確な結論が得られませんでした.
- これらの結果を理解することは 患者のカウンセリングと期待の管理に不可欠です
研究 の 目的:
- 癌の生存者における無助妊娠における 生児率を体系的に検討する.
- 癌とその治療が 妊活や妊娠に与える影響を特定する
- 癌の生存者の無助妊娠における親と胎児の結果を評価する.
主な方法:
- 2025年4月まで主要なデータベース (PubMed,Embase,Cochrane,Scopus) で検索した.
- 1,185件の単一の引用を 盲目的に独立的に調査した.
- 生存率と二次的な結果に焦点を当てた43の記事から抽出したデータ.
主要な成果:
- 乳がんの生存者および幹細胞移植または腹腔皮質放射線治療を受けた患者の生児率の低下が観察されました.
- 乳がんや婦人科がんの生存者における妊娠中絶率の増加
- 放射線治療は妊娠年齢に比べて小さくて出生体重が低い乳児の割合を高め,乳がんの生存者は早産の割合を高めました.
結論:
- 癌の生存者にとって 無助妊娠は可能ですが 特定の癌や治療法により 生児の割合は低下します
- 妊産婦と新生児の合併症は 特定の生存者のグループではより頻繁です
- パーソナライズされた生殖保全カウンセリングは 癌の治療において 健全な生殖選択をするために不可欠です
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