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Updated: Sep 10, 2025

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

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栄養素センシング受容体GPRC6AはmTORC1のシグナル伝達とTauの生物学を調節する

Chao Ma1, Kelsey Campbell2, Andrii Kovalenko3

  • 1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; Sanders-Brown Center on Aging, Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, United States.

Neurobiology of disease
|August 23, 2025
PubMed
まとめ

アルギニン感知経路は,タオパシーにおけるラパミシン複合体1 (mTORC1) 信号伝達のメカニズムを乱します. Gタンパク質結合受容体6C (GPRC6A) を標的にすることで,タウの蓄積を減少させ,アルツハイマー病および関連疾患に対する潜在的な治療戦略を提供します.

キーワード:
アルツハイマー病アルギニンの代謝アルギニンセンサーオートファジーGPCR についてプロテイン病タウ PS19

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Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

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