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Updated: Jun 14, 2026

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
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代謝機能障害に関連した脂肪肝炎 (ION224- CS2) に対するアンチセンセスオリゴヌクレオチドDGAT-2阻害剤,ION224: 51週間の多センター,ランダム化,ダブルブラインド,プラセボ対照,第2相試験の結果

Rohit Loomba1, Erin Morgan2, Keyvan Yousefi2

  • 1Metabolic Dysfunction-Associated Steatotic Liver Disease Research Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA.

Lancet (London, England)
|August 23, 2025
PubMed
まとめ

ION224は,DGAT2の反感覚阻害剤であり,代謝機能障害に関連した脂肪肝炎 (MASH) の治療において有望である. この薬はMASHと線維症の患者で有意な組織学的改善を示し,安全で効果的な治療戦略を示しています.

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