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Updated: Sep 10, 2025

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cAMP-PKAシグナリングは,ボラをリン酸化することによってミトーシスを開始する

Min Zhu1, Shinan Zhou1, Yingqi Zhang1

  • 1Department of Gynecologic Oncology, Women's Hospital, School of Medicine and MOE Laboratory of Biosystems Homeostasis & Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Nature communications
|August 23, 2025
PubMed
まとめ

周期的なAMP (cAMP) 信号は,ボラをリン酸化するタンパク質キナーゼA (PKA) を活性化することによってミトーシスを開始します. これはボラ-オーロラA相互作用を誘発し,細胞サイクル進行のためのPoloのようなキナーゼ1 (Plk1) を活性化します.

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