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Updated: Jun 21, 2026

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
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Published on: November 11, 2014

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アルファリポ酸サプリメントは,フリードリヒ症の細胞モデルにおける病理学的変化を改善する

Marta Talaverón-Rey1, Diana Reche-López1, Suleva Povea-Cabello1,2

  • 1Centro Andaluz de Biología del Desarrollo (CSIC-Junta de Andalucía-UPO), Universidad Pablo de Olavide, 41013, Seville, Spain.

Orphanet journal of rare diseases
|August 23, 2025
PubMed
まとめ

アルファリポ酸 (ALA) は,細胞の欠陥を部分的に修正することによって,フリードリヒ症 (FRDA) の治療に希望を示しています. この抗酸化物質はFRDAモデルにおいてフラタキシン発現を増加させ,疾患の表型を逆転させる可能性がある.

キーワード:
フィブロブラストフラタキシンフリードリヒ・アタクシア誘導ニューロン鉄の蓄積ミトコンドリアアルファリポ酸

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis08:59

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