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Updated: Sep 10, 2025

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
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KRAS ((G12D)) 選択分解剤ASP3082の発見

Tomohiro Yoshinari1, Takeyuki Nagashima2, Hiroki Ishioka2

  • 1Engineered Small Molecules, Astellas Pharma Inc., Tsukuba, Japan. tomohiro.yoshinari@astellas.com.

Communications chemistry
|August 23, 2025
PubMed
まとめ

研究者はASP3082を開発し,がんにおける一般的なKRAS (G12D) 変異を標的とした新しい分解剤を開発した. この化合物はKRAS ((G12D)) タンパク質を効果的に分解し,KRAS ((G12D)) 変異がんの治療に有望である.

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