統合失調症における血液および神経細胞外膀のミトコンドリア障害
A Ankeeta1, Ashutosh Tripathi2, Bindu Pillai2
1Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. ankeeta.lnu@uth.tmc.edu.
まとめ
統合失調症スペクトル障害 (SSD) はミトコンドリア機能障害に関連しています. 血液とニューロンのミトコンドリア DNA (cf-mtDNA) が増加すると,SSDのバイオマーカーとして機能し,脳乳酸レベルに関連している.
科学分野:
- 神経科学
- 生物化学
- 遺伝学
背景:
- ミトコンドリア機能障害は統合失調症スペクトル障害 (SSD) のような神経精神疾患に関連しています.
- SSDにおける脳ミトコンドリア機能を in vivoで評価することは困難です.
- 血中の細胞フリーミトコンドリアDNA (cf-mtDNA) とニューロンの細胞外小胞 (nEV) はバイオマーカーとして提案されている.
研究 の 目的:
- 血中のcf-mtDNA濃度の上昇とnEVをSSDの潜在的なバイオマーカーとして調査する.
- 磁気共鳴光譜法 (MRS) で測定されたcf-mtDNAレベルと脳の代謝産物との関連を調査する.
- SSD患者の発達ストレス,トラウマ,cf-mtDNAレベルとの関係を調べる.
主な方法:
- 血液のcf-mtDNAは58人のSSD患者と33人の健康な対照群で測定された.
- nEV mtDNAと脳メタボリート濃度 (MRSを用いて) はサブグループで評価された.
- cf-mtDNA,代謝産物,およびストレス/トラウマの経歴を相関させるための統計的分析が行われました.
主要な成果:
- SSDの患者は,対照群と比較して,血液とnEVの両方において,cf- mtDNAの有意な増加を示した.
- cf-mtDNA濃度の上昇は,SSD患者の前帯状皮質の乳酸+濃度の上昇と相関していた.
- 発達上のストレスとトラウマの増加は,SSD患者の高いcf- mtDNAレベルと関連していました.
結論:
- 血液とnEV cf-mtDNAは,SSDにおけるミトコンドリア機能障害の評価のためのアクセス可能なバイオマーカーとして有望である.
- これらのバイオマーカーは統合失調症の異常なバイオエネルギー経路を明らかにするのに役立ちます.
- 臨床応用のためにさらなる複製と開発が必要である.
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