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Updated: Sep 10, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

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RCN3は,GRP78-PI3K-AKTシグナル伝達経路を調節することによって,結腸直腸がんにおける腫瘍プロモーターとして機能する

Mei Huang1,2, Bingru Qin1, Zhefan Xie3

  • 1Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Oncogene
|August 23, 2025
PubMed
まとめ

レチキュロカルビン3 (RCN3) は結腸直腸がん (CRC) で上位調節され,腫瘍の成長と転移を促進します. RCN3をターゲットにすることで,CRC患者の治療結果を改善するための新しい治療戦略を提供することができる.

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mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
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