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Updated: Sep 10, 2025

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
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Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

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空間的宿主-微生物群のプロフィーリングは,小児性クローン病における細菌関連宿主転写変化を示しています

Sooyoung Jang1, Eun Joo Lee2, Sowon Park3

  • 1Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Microbiome
|August 23, 2025
PubMed
まとめ

小児クローン病 (CD) の腸内微生物群の空間プロファイリングは,疾患の重症度と相関する組織内のバクテリアの増加を示しています. この研究は,主要な細菌種と宿主反応を特定し,CDの病原性および潜在的な治療標的に関する新しい洞察を提供します.

キーワード:
胃腸の微生物群ホストと微生物の相互作用マルチオミクス

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Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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