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Updated: Sep 10, 2025

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横断傷害後のサイアス神経の単細胞転写図

Yiben Ouyang1,2, Mingqian Yu1, Tieyuan Zhang2,3

  • 1School of Medicine, Nankai University, No. 94, Weijin Road, Nankai District, Tianjin, 300071, PR China.

Journal of neuroinflammation
|August 24, 2025
PubMed
まとめ

周辺神経の損傷は 回復を阻害する この研究は,単細胞配列解析を用いて,坐骨神経の損傷後の細胞変化をマッピングし,重要な免疫細胞と膠質細胞の役割と,神経再生の改善のための潜在的な治療標的を明らかにした.

キーワード:
TGF−βシグナリンググリア細胞の再プログラムマクロファージの異質性神経再生神経線維細胞膠の相互作用坐骨神経の切断単細胞RNA-seq

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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