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Updated: Sep 10, 2025

05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
348
糖尿病患者のセマグルチド過剰投与: 自殺傾向と多臓器不全
Doron Zamir1,2, Yaniv S Ovadia1,3, Ofer Ben-Bassat4
1Department of Internal Medicine D, Barzilai University Medical Center, Ashkelon, Israel.
The American journal of case reports
|August 24, 2025
まとめ
セマグルチドのようなグルカゴン類ペプチド-1受容体アゴニスト (GLP- 1 RAs) はますます使用されています. セマグルチドの過剰摂取で重症になった患者の症例報告は,精神疾患のスクリーニングの必要性を示唆している.
科学分野:
- 内分泌学
- 薬理学について
- 胃腸内科
背景:
- グルカゴン類ペプチド-1受容体アゴニスト (GLP- 1 RAs) は,糖尿病と体重管理において使用が増加しています.
- セマグルチドの処方箋は,承認された用途と非承認された用途の両方に増加しました.
- GLP-1 RAsと自殺傾向との潜在的な関連が示唆されている.
研究 の 目的:
- 自己投与セマグルチドの過剰摂取による自殺行為と不良結果の珍しい症例を報告する.
- セマグルチドの使用と過剰摂取に関連する潜在的なリスクを強調する.
主な方法:
- 67歳の男性 糖尿病と肥満の症例報告
- セマグルチドの使用に関する詳細な臨床報告,治療,および患者歴
- 患者の自己注射による過剰摂取と 自殺傾向との関連分析
主要な成果:
- 多臓器不全,低血糖症,胆固醇性肝機能障害,十二指腸潰瘍が,セマグルチドの過量注射により発生した.
- 十二指腸潰瘍の治癒を含む治療により臨床状態が改善した.
- 患者の過去と報告された不快感を考慮して,過剰摂取は潜在的に自殺行為とみなされた.
結論:
- セマグルチドなどのGLP-1RAを処方された患者は,精神疾患のスクリーニングを受けるべきである.
- 多臓器不全は,セマグルチドで治療された急性疾患の患者で考慮されるべきです.
- このケースは,GLP-1RAsを使用する患者における不良精神疾患および過剰投与のモニタリングの重要性を強調しています.
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