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Updated: Sep 10, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
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A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

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エノンの公式α- アリレーションによるアレクチニブ合成

Saumya Singh1, Arun Yadav1,2, Chandra Bhushan Tripathi1,2

  • 1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.

Organic letters
|August 24, 2025
PubMed
まとめ

ALK陽性非小細胞肺がんの重要な治療法であるアレクチニブの新しい合成経路が開発されました. この効率的な方法は,容易に入手可能な材料と重要な結合反応を利用し,高純度な薬物を生成します.

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