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Updated: Sep 10, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

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MYCの放出は,がん細胞をN-ミリスチロトランスファーゼ抑制に敏感にする

Gregor A Lueg1, James Zhang2, Monica Faronato1

  • 1Department of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London, 82 Wood Lane, W12 0BZ London, UK; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK.

Cell reports
|August 24, 2025
PubMed
まとめ

人間のN-ミリストイルトランスファーゼ (NMTs) はがん標的である. IMP-1320でNMTを阻害すると,MYCが誘発する癌は敏感で,毒性なくミトコンドリア機能障害と腫瘍抑制につながります.

キーワード:
CP: がんについてCP: 分子生物学コンプレックスIMYC についてMYCN についてN-ミリスチル化N-ミリストイルトランスフェラーゼNDUFAF4NMT

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