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前立腺がんの男性における多次元的な疲労の生物行動相関:二次データ分析
Kristin Dickinson1, Kevin Kupzyk1, Christopher Wichman2
1College of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
まとめ
前立腺がんの男性におけるがん関連疲労 (CRF) は,通常,放射線治療中に悪化するが,その後は改善する. IL-8のような特定の症状と炎症マーカーは,異なるCRFの次元と相関し,対応した管理戦略を告げる.
科学分野:
- 腫瘍学
- 精神神経免疫学
- 癌 の 生存 率
背景:
- 癌に関連した疲労 (CRF) は,放射線治療を受けている前立腺がん患者の一般的な苦痛な症状です.
- CRFとその相関体の多次元的な性質を理解することは,効果的な患者管理に不可欠です.
研究 の 目的:
- 前立腺がんの男性における多次元のCRFの経路を放射線療法中および後に調べる.
- 異なるCRF次元に関連した,人口統計的,臨床的,同時発生症状,および炎症性サイトカインを含む,生物行動的相関性を特定する.
主な方法:
- 放射線治療を受けた68人の前立腺がん患者の長期研究による二次分析.
- MFSI- SFアンケートを使用して,治療開始時,治療終了時,および治療後6ヶ月と24ヶ月で評価された多次元CRF.
- CRFの測定値と患者の報告したアウトカムとIL-8バイオマーカーのレベルとの間の相関を計算した.
主要な成果:
- ほとんどのCRF (一般的,身体的,精神的) は,治療中に悪化し,治療後の改善;感情的疲労は安定したままでした.
- 治療中に併発する症状 (不安,うつ,痛み,睡眠障害) は,CRFの大きさと相関していた.
- 治療後の前立腺がんリスク群,併発症状,およびIL-8は,CRFの測定値と関連していました.
結論:
- 前立腺がん患者におけるCRFの異なる次元には,異なる生物行動および生物学的相関関係がある.
- CRFの特定の側面をターゲットにした 調整された評価と介入は 管理の最適化と患者の成果の改善に不可欠です
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