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Updated: Sep 10, 2025

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固体分散におけるポリマーと水溶性の低いロラタジンの分子相互作用に関する洞察

Jincao Tang1, Huai He1, Chi Ma1

  • 1Chongqing Key Laboratory of Digitalization of Pharmaceutical Processes, College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.

Chemical & pharmaceutical bulletin
|August 24, 2025
PubMed
まとめ

分子動力学シミュレーションにより,ロラタジン (LOR) のポリマーとの混合性が予測され,薬剤の溶解性が向上する. この方法は,溶解性が低い薬剤の固体分散 (SD) の生成を加速する.

キーワード:
相互作用ロラタジン混合性について分子動力学ポリマー固体分散

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