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Updated: Jul 16, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

アンジオテンシンII誘発によるCHK1のセルリン-280へのリン酸化は,JAK1の直接リン酸化によって心臓のリモデリングを促し,マウンの心筋細胞におけるJAK1-STATのシグナリングを活性化させる

Zheng Xu1,2, Yihan Shen2, Xiaoting Luo3

  • 1Heart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.

British journal of pharmacology
|August 24, 2025
PubMed
まとめ

チェックポイントキナーゼ1 (CHK1) の活性化は,JAK1-STAT3経路経由で心臓の改造を誘発する. CHK1を阻害することは 心不全の潜在的な治療法です

キーワード:
JAK1 についてSTAT3 についてアンジオテンシンII心臓の改造チェックポイントキナーゼ1

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