腸:脳への扉と鍵
Xiaohan Zhang1,2, Yunsheng Yang1,3
1Microbiota Lab and Clinical Division of Microbiota, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Chinese medical journal
|August 24, 2025
まとめ
腸内微生物群は様々な経路で 脳機能や神経発達に影響します 腸内の栄養素や微生物を標的とした治療は 脳や神経精神疾患の 新規治療の可能性を秘めています
科学分野:
- 神経科学
- 胃腸内科
- 微生物学
背景:
- 脳の複雑さは 密封された性質のため 直接的に研究するのは困難です
- 腸は消化だけでなく 脳の健康と機能にも 重要な役割を果たします
- 腸と脳の相互作用は 神経発達と脳全体の機能に不可欠であると認識されつつあります
研究 の 目的:
- 脳科学と神経精神疾患における 腸の役割を探るため
- 脳の機能を理解する鍵となる領域として 腸を強調します
- 新しい治療戦略を開発する 腸の可能性を特定する
主な方法:
- 腸-脳軸経路に関する既存の文献のレビュー
- 神経,神経免疫,内分泌,微生物信号の分析
- 中枢神経系に対する栄養と微生物の影響の調査.
主要な成果:
- 神経と微生物の信号伝達を含む複数の腸-脳相互作用経路が特定されました.
- 腸内微生物は 食物と腸内環境との相互作用によって 腸内脳との通信を調整します
- 腸は脳神経の発達と機能に不可欠な 栄養素と電解質を供給します
結論:
- 腸は脳科学や 神経精神疾患を理解する 重要な門戸です
- 腸内栄養と微生物は 神経調節の重要な調節因子です
- 腸をターゲットにすると 脳や神経精神疾患の 新規治療法に希望が持たれます
関連する概念動画
Neural Regulation
39.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.9K
Physiology of Enteric Nervous System and Gut Health
416
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
416
Enteric Nervous System: Regulation of GI Motor Activity
755
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
755
Nerve Supply of the GI Tract
1.7K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
1.7K
Functional Brain Systems: Limbic System
3.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.9K
Physiology of the Gastrointestinal System II: Digestion and Absorption
942
The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
942


