2型糖尿病と心血管疾患患者の転倒リスク増加: 系統的レビューとメタ解析

Aksayan Arunanthy Mahalingasivam¹, Peter Vestergaard^2,3, Nicklas Højgaard-Hessellund Rasmussen^2,3

¹Steno Diabetes Centre North Denmark, Aalborg University Hospital, Aalborg, Denmark. aksayan.mahalingasivam@rn.dk.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

|August 24, 2025

まとめ

2型糖尿病や心血管疾患の患者は転倒のリスクが高くなりますこの関連性は明らかですが,この集団の減少に寄与する特定の心血管疾患については,さらなる研究が必要です.

科学分野:

ゲロントロジー
心臓病科
内分泌学

背景:

2型糖尿病 (T2D) は,転倒のリスクの増加と関連しています.
心血管疾患 (CVD) はT2D患者の転倒リスクをさらに悪化させる.
T2D,CVD,および転倒リスクの間の特定の相互作用は完全に理解されていません.

研究の目的:

T2DとCVDが共存している人の転倒リスクに関する証拠を体系的に検討し,メタ分析する.
併発性T2DとCVDに関連する転倒リスクの大きさを推定する.

主な方法:

PRISMAのガイドラインに従うPubMed,Embase,Cochraneのデータベースの体系的な文献検索
T2D患者の転倒リスクを評価した研究のメタ分析.
JADAD,NOS,GRADEツールを用いた品質評価

主要な成果:

T2Dと共存するCVDの患者は,T2Dのみの患者と比較して,転倒のリスクが著しく高い.
メタ解析では,心血管疾患のT2D患者における転倒率は1. 29 (95%CI1. 03-1.63) であった.
特定の心血管疾患 (高血圧,心不全など) との関連結論は得られなかった.

結論:

T2DとCVDの共存は,転倒の有病率の増加と関連しています.
特定のCVDとT2D患者の転倒リスクとの間の決定的な因果関係を確立するには,現在の証拠は不十分です.
この集団の減少に寄与するメカニズムと特定の要因を明らかにするためにさらなる研究が必要である.

キーワード:

バランス心血管疾患糖尿病2型秋に審査

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