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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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ポリドパミンでコーティングされた二重エムルションカプセル

Hyojun Lee1, Giyeong Nam1, Daehoon Han2

  • 1School of Chemical Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.

Scientific reports
|August 24, 2025
PubMed
まとめ

ポリドパミン (PDA) コーティングは,ダブルエムルションカプセル (DEC) の安定性を高め,薬の被動的な漏れを軽減します. PDAでコーティングされたDECは,光熱活性化によるオンデマンドの薬物放出を提供し,制御された投与システムを改善します.

キーワード:
ダブルエムルションカプセル薬物の放出マイクロ流体パッシブ・リークポリドパミンコーティング

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科学分野:

  • バイオマテリアル科学
  • 薬物投与システム
  • ポリマー化学

背景:

  • ダブルエムルション (DE) は,水性および水害性の薬物をカプセル化しますが,制御された放出のための安定性は欠けている.
  • ダブルエムルションカプセル (DEC) は安定性を高めますが,多孔な殻を通して薬の拡散に苦しんでいます.
  • ポリドパミン (PDA) はバイオコンパティブルで安定したポリマーで,強い粘着性があり,生物学的コーティングに適しています.

研究 の 目的:

  • 二重エムルションカプセル (DEC) のポリドパミン (PDA) コーティングを調査し,安定性を高め,薬物の放出を制御する.
  • PDAコーティングのDECからの被動的な薬物漏洩への影響を評価する.
  • 光熱活性化によるPDAコーティングのDECからのオンデマンド薬剤の放出を実証する.

主な方法:

  • ダブルエムルションカプセル (DEC) の製造
  • 最適な条件下でDECをポリドパミン (PDA) でコーティングする.
  • 時間の経過による被動的な薬物漏洩の評価
  • 近赤外線 (NIR) レーザー照射によって誘発されたオンデマンドの薬物放出の実証.

主要な成果:

  • PDAコーティングは,DECから受動的な薬物漏れを,コーティングされていないDECと比較して,約20%で8日間にわたって大幅に減少させた.
  • 効率的な表面カバーと安定性の強化のために最適化されたPDAコーティング条件が確立されました.
  • NIRレーザー照射によるPDA層の光熱加熱により,需要に応じて薬物の放出が成功しました.

結論:

  • PDAでコーティングされたDECは,安定した制御された薬物投与のための有望なプラットフォームです.
  • PDAの光熱特性により 調節可能な薬剤が要求に応じて放出され 治療の可能性が向上します
  • このアプローチは,標的型薬物投与,インプラント治療,精密医療の応用に進歩をもたらします.