コラーゲン由来のヒドロキシプロリン含有サイクルディペプチドは,UVB照射を受けた表皮ケラチノシートの光衰に関連する炎症反応を予防する
Yuki Kumazawa1, Kazunori Mizuno1, Yuki Taga1
1Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Photochemistry and photobiology
|August 25, 2025
まとめ
反応性酸素種 (ROS) と炎症を減らすことで皮膚の光衰老を効果的に抑制します. これらの化合物は 皮膚ケアや機能的な食品の 抗老化成分として有望です
科学分野:
- 皮膚科と化粧品
- 生物化学と分子生物学
背景:
- 反応性酸素種 (ROS) は,紫外線によって誘発される皮膚の光老化の主要な要因です.
- 以前は,ヒドロキシプロリン (Hyp) 含有サイクルディペプチド (cyclo(X-Hyp)) で濃縮された新しいコラーゲン水解剤 (H-GDCH) が開発された.
研究 の 目的:
- ヒトの皮膚細胞におけるUVB誘発の炎症に対するサイクロ・X・ヒップとH・GDCHの抗老化効果を調査する.
- ROSのスキャビング能力と抗炎症メカニズムを評価する.
主な方法:
- 正常なヒトの表皮ケラチノサイト (NHEK) がUVB照射を受けた.
- 細胞内ROS濃度,炎症経路 (NF-κB,MAPK),MMP- 2/ MMP- 9発現,およびIV型コラーゲン濃度が評価されました.
- ヒトの皮膚への浸透は,ヒトの皮膚への浸透を用いて評価された.
主要な成果:
- 線形ダイペプチドとProを含むサイクルダイペプチドと比較して,より優れたROS除去活性を示した.
- Cyclo ((X-Hyp) は,UVBによるNF-κBとMAPK経路の活性化を抑制し,MMP- 2/ MMP- 9を減少させ,IV型コラーゲンを保存した.
- H-GDCHはまた,UVB誘発のROS生成と下流の炎症反応を抑制しました.
- ヒトの皮膚に効果的に浸透した.
結論:
- ROSと炎症を和らげることで,重要な抗老化の可能性を秘めている.
- これらの化合物は皮膚の健康を狙った 化粧品や機能性食品の有望な候補です
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