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Updated: May 4, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Published on: January 8, 2015

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小説"C" MAPT/Tauの拡散のためのelegansモデルでは,エンドリソームの完全性および種子のMAPT/Tauの集積にとって重要な遺伝子を明らかにします

Carl Alexander Sandhof1,2, Nicole Martin3, Jessica Tittelmeier3

  • 1Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany.

Autophagy
|August 25, 2025
PubMed
まとめ

研究者らは,MAPT/Tau病理がアルツハイマー病のような神経変性疾患で広がるのを防ぐために不可欠な,エンドリソームの整合性を維持する細胞経路を特定しました.

キーワード:
アルツハイマー病エンドリソソーム系リンソーム膜の浸透神経変性プリオンのような広がりタオパシー

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