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Updated: Sep 10, 2025

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ハンティングチンタンパク質のNt17領域による曲線感知の研究

Neha Nanajkar1, Abhilash Sahoo2,3, Shelli L Frey4

  • 1Department of Biology, University of Maryland, College Park, Maryland 20742, United States.

ACS chemical neuroscience
|August 25, 2025
PubMed
まとめ

ハンティングチンタンパク質 (Nt17) のN末端ドメインは,脂質包装の欠陥を感知するPhe残留によって,優遇的に曲線膜に結合する. この相互作用は,ハンティングチンタンパク質の機能を理解するために不可欠です.

キーワード:
ハンティントン病Nt17 について集積するアンフィパティック・ヘリックス曲線感知神経変性

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Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
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