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Updated: Sep 10, 2025

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Published on: April 3, 2014

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ニュクレオシド3'-H-フォスフォノチオアートの化学選択凝縮によるP-改変化学オリゴヌクレオチドの合成

Harumi Okutsu1, Yuhei Takahashi1, Tomomi Shiraishi1

  • 1Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Katsushika-ku, Tokyo 125-8585, Japan.

The Journal of organic chemistry
|August 25, 2025
PubMed
まとめ

研究者は,改造されたオリゴヌクレオチドを合成するための新しい方法を開発しました. この技術は,ニュクレオシド3′-H-フォスフォノチオアートモノエステルの化学選択性を制御し,多様なP-改変キメリックオリゴヌクレオチドの生成を可能にします.

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