1990年から2021年までの全粒穀物の少ない食生活による結腸癌の世界疾病負担とその2050年の予測:2021年の世界疾病負担の分析
Mei Yang1, Gansheng Huang1, Feng Jiang1
1The Eighth Hospital of Wuhan, Wuhan, China.
Frontiers in nutrition
|August 25, 2025
まとめ
大腸がんによる死亡率は1990年から2021年の間に83%増加した. 年齢で標準化された割合が低下しているにもかかわらず,人口増加と高齢化により絶対的なCRC負担は増加しています.
科学分野:
- 世界保健
- 流行病学について
- 腫瘍学
背景:
- 結腸直腸がん (CRC) は,世界的に大きな健康問題です.
- 全粒粉の摂取量が少ないような食生活要因は,CRCの発症に関与しています.
- 病気の負荷の進化を理解することは公衆衛生の介入に不可欠です.
研究 の 目的:
- 1990年から2021年までの低全穀食に関連するCRC病重の傾向を分析する.
- 2050年までの食事に関する将来のCRCの負担を予測する.
- CRCの標的型予防と制御戦略を策定する
主な方法:
- 204か国・地域における2021年世界疾病負荷 (GBD) のデータを活用した.
- 死亡,DALY,ASMR,ASDRを用いてCRCの負担を評価した.
- 負荷ドライバーの将来の予測と分解分析のためのベイジアン年齢期-コホート (BAPC) モデリングを使用した.
主要な成果:
- 1990年から2021年までの間に,全粒穀物食品が少ないCRCによる死亡率は82.94%増加し,DALYは70.3%増加しました.
- 地域的な異質性が顕著で,SDIが低から中程度の地域が最も急速に増加しています.
- 病気の負担は50歳から85歳の年齢層で最も高く,男性の方がリスクが高い.人口増加が負担の増加の主な要因とされています.
結論:
- 全穀食が少ないため,年齢基準のCRCの発生率は世界的に減少していますが,絶対的な負担は増加しています.
- 低量の全粒粉の摂取は,CRCの有意で修正可能な危険因子です.
- 将来の予測は,主に人口増加と高齢化による絶対CRC負担の継続的な増加を示しています.
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