メラトニンとビフィド菌の相互作用を理解する

Sonia Mirjam Rizzo¹, Giulia Longhi¹, Chiara Tarracchini¹

¹Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma 43124, Italy.

Microbiome research reports

|August 25, 2025

まとめ

人間の牛乳

科学分野:

微生物学
人間の生理学
分子生物学

背景:

腸内微生物群は複雑な微生物集団で誕生時に形成され授乳などの要因に影響されます
母乳にはメラトニンというホルモンが含まれており睡眠と覚醒のサイクルを調整し新生児の昼夜リズムを確立するのに不可欠です
乳の成分と乳児の腸内微生物の相互作用を理解することは乳児の健康に不可欠です

研究の目的:

ヒトのメラトニンと乳児の腸内微生物群の分子相互作用を研究する.
乳幼児の腸内細菌の機能と遺伝子発現にメラトニンがどう影響するか調べる

主な方法:

分子通信を評価するために in vitro 測定を用いた.
微生物の反応を分析するために機能的ゲノムアプローチを採用した.

主要な成果:

メラトニンは,トランスクリプションレベルとフェノタイプレベルの両方で,ビフィド菌種に明確な機能的影響を誘導した.
メラトニンの腸細胞への微生物粘着に対する種別による影響

結論:

Bifidobacterium bifidumは,試験されたビフィドバクテリア分類群の中でメラトニンとの最も有意な分子相互作用を示した.
メラトニンは,乳児の腸内微生物の組成と機能を調節する上で重要な役割を果たし,特に特定のビフィド菌との相互作用を通して.

キーワード:

CST についてメラトニンビフィド菌腸内微生物ホルモン

さらに関連する動画

06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.2K

11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K

関連する概念動画

01:19

Management of Insomnia

320

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...

320

01:02

The Pineal Gland

2.5K

The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...

2.5K

02:19

Circadian Rhythms and Gene Regulation

4.1K

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

4.1K

01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

241

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...

241

01:19

Factors Affecting Drug Biotransformation: Biological

235

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...

235

関連する実験動画