クローン 病 の 食事 傾向: 健康 な 患者 と 比較
Brian Devorkin1, Fabio Cominelli2,3,4,5,6, Abigail Raffner Basson3,4,7
1Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Current research in complementary & alternative medicine
|August 25, 2025
まとめ
クローン病の患者は 健康な人と比較して 炎症を誘発する栄養素を多く摂取し 乳製品や野菜などの栄養素濃度の低い食品を摂取します
科学分野:
- 胃腸内科
- 栄養学
- 慢性疾患 の 管理
背景:
- クローン病 (CD) は慢性的な炎症性疾患で,生活の質に影響を及ぼします.
- ダイエットはCDの炎症と病気の活動に大きな影響を与えます.
- 多くのCD患者の現在の食事には,臨床的助言に反する炎症促進成分が含まれている可能性があります.
研究 の 目的:
- クローン病の患者と健康な対照群の食事パターンを比較する
- CDへの介入のための特定の食事成分と栄養目標の特定
- CDにおける食事と疾患の活動との関係を調査する.
主な方法:
- 52人の成人の参加者 (29人のCD,23人のHC) を対象とした調査です.
- 参加者は大学病院のクリーブランド医療センターの消化器疾患研究所から募集されました.
- 栄養素の摂取と食事のガイドラインの遵守を比較するために,食事の摂取を評価した.
主要な成果:
- CD患者はフルークトーゼ,総タンパク質,アラキド酸,ホワイトポテトの摂取量が高かった.
- 乳製品,野菜,豆類の摂取量はHC患者より大幅に低かった.
- HEI-2015の全体的なスコアが低い傾向は,CDの参加者の食事の質の低下を示しています.
結論:
- クローン病の患者は,炎症を誘発する栄養素の摂取量が高いと特徴づけられる,最適でない食事パターンを有することがあります.
- 炎症を誘発する栄養素を減らし,栄養素濃度の高い食品を増やす戦略は,CDの管理に推奨されます.
- これらの発見を検証し,CDにおける栄養介入の臨床的意味を探求するには,さらなる研究が必要である.
関連する概念動画
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
419
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
419
01:30Inflammatory Bowel Disease II: Crohn's Disease
382
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
382
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
267
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
267
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
202
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
202
01:17Chronic Bowel Disorders: Introduction
540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
321
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
321