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Updated: Sep 10, 2025

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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B細胞転位遺伝子2の補償変異のメカニズムとしての二次アロステリック制御

Nicholas J Ose1, Paul Campitelli1, Tushar Modi1

  • 1Department of Physics and Center for Biological Physics, Arizona State University, Tempe, Arizona, USA.

Protein science : a publication of the Protein Society
|August 25, 2025
PubMed
まとめ

BTG2タンパク質の乱れた尾の補償性突然変異は,病気に関連した突然変異によって機能が妨げられた状態を回復することができます. この研究は タンパク質の機能を救う新しいアロステリックメカニズムを明らかにし 治療の洞察をもたらしました

キーワード:
アロステリー本質的に無秩序な地域線形応答理論分子ダイナミクスシミュレーションタンパク質の動態

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