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Updated: Sep 10, 2025

Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking
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Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking

Published on: March 16, 2017

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SFTSVは,AXL-キナーゼによって活性化されたPI3K-PLC依存マクロピノシトーシス経由でAXL/GAS6を利用する

Zecheng Jin1,2,3, Shuhei Taguwa1,2,3, Junki Hirano1,2

  • 1Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan.

Journal of virology
|August 25, 2025
PubMed
まとめ

血小板減少症候群ウイルス (SFTSV) による重度の発熱は,受容体チロシンキナーゼであるAXLを用いて細胞に侵入する. この発見はSFTSV感染の新たな経路を明らかにし,AXLを潜在的な治療標的として提供します.

キーワード:
AXL についてCRISPRのアクティベーションスクリーニングGAS6 についてPI3K についてPLC についてSFTSV自己リン酸化マクロピノサイトーシス

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