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Updated: Sep 10, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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Published on: December 3, 2020

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哺乳期生理学ベースの薬理学モデリングの適用は,被動的に拡散された薬物の乳中の曝露を予測する

Ruhul Kayesh1, Michelle Pressly1, Daphne Guinn1

  • 1Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Journal of clinical pharmacology
|August 25, 2025
PubMed
まとめ

生理学的に根拠のある薬動学モデル (PBPK) は,非輸送基板の乳中の薬剤濃度を正確に予測します. これらのモデルでは,乳児の薬物曝露を哺乳期経由で評価する可能性がある.

キーワード:
PBPK についてアルプラゾラムアテノロールエシタロプラム哺乳期モデル

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