葉酸の強化と遅発の結腸直腸がんリスク: 世界的な証拠の体系的な評価
Tongtong Li1, Yuan Li1, Lina Yin2
1Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
International journal of cancer
|August 25, 2025
まとめ
強制的な葉酸補給は,遅発の結腸直腸癌 (LOCRC) の発生率の低下と関連しています. 総合的な分析では,がん予防におけるLOCRCの役割を支持する強化政策により,LOCRCの発生率が低下していることが示されています.
科学分野:
- 公衆衛生
- 栄養学的流行病学
- 癌 の 予防
背景:
- 葉酸強化の政策は世界的に異なっており,潜在的な健康への影響に関する議論が続いている.
- 結腸直腸がんは,特に遅発の形態は,世界的な健康上の重大な問題であり続けています.
- 葉酸補給と癌発生率の関係を理解することは公衆衛生政策にとって極めて重要です.
研究 の 目的:
- 強制的な葉酸補給政策と遅発性大腸がん (LOCRC) の発生率の間の世界的な関連性を調査する.
- 葉酸補給が義務付けられているか,義務付けられていない国におけるLOCRCの発生率を比較する.
- 葉酸強化の実施前と後の発生傾向を分析する.
主な方法:
- WHO加盟国193カ国の葉酸強化政策の体系的評価
- 各国の年齢標準化LOCRC発生率の分析
- 強化の種類とLOCRC発生率との関連を調査する生態学的研究の設計,傾向分析のための結合点回帰.
主要な成果:
- フォリック酸の強化は69カ国で義務付けられ,124カ国で義務付けられませんでした.
- LOCRCの発生率は,強制的な強化国では10万人に70. 8で,強化されていない国では84. 0でした.
- 米国とカナダでは,強化後のLOCRC発生傾向は強化前の期間と比較してより急速な減少を示しました.
結論:
- 強制的な葉酸補給政策は,遅発の結腸直腸癌の発生率の減少と関連しています.
- ガン予防の戦略として 葉酸の強化を支持するグローバルデータです
- 発見は,公衆衛生強化政策の情報提供と移行のための科学的基盤を提供します.
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