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Updated: Sep 10, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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CD44v6 CAR- T 細胞 ターゲット DNMT3A- 変異性AML:デシタビンによるシナギスティック強化

Hui-Min Li1, Yi-Mei Que1, Xiao-Ya Cai1

  • 1Department of Hematology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China.

Current medical science
|August 25, 2025
PubMed
まとめ

CD44v6を標的とした化学抗原受容体T細胞 (CAR- T) 治療は,DNMT3A変異を有する急性骨髄性白血病 (AML) に対して有望である. デシタビンは,AML細胞のCD44v6発現を増加させることで,CAR- Tの有効性を高めます.

キーワード:
DNMT3A変異急性骨髄性白血病CD44v6 についてキメリック抗原受容体併用療法DNAメチル化デシタビンエピジェネティック・レグレーション

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