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Updated: Sep 10, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Published on: September 26, 2013

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多発性硬化症における炎症性Th17応答におけるCD5信号の役割

Katrin Pape1, Nicholas Hanuscheck1, Samantha Schmaul1

  • 1Department of Neurology, Research Center for Immunotherapy (FZI) and Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Brain : a journal of neurology
|August 25, 2025
PubMed
まとめ

Tヘルパー17 (Th17) 細胞のCD5- CK2- STAT3経路をターゲットにすることで,多発性硬化症 (MS) の炎症が軽減されます. CD5を阻害することで,炎症誘発性サイトカインの産生と細胞毒性効果が抑制され,MSの新たな治療方法が提供されます.

キーワード:
CD5 についてCK2 についてTh17 細胞免疫調節多発性硬化症

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