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Updated: Sep 10, 2025

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
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Plasmodium falciparumマラリアにおける多剤耐性の進化に対する再結合の影響

Kien Trung Tran1, Tran Dang Nguyen1, Daniel B Weissman2

  • 1Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, Pennsylvania, United States of America.

PLoS computational biology
|August 25, 2025
PubMed
まとめ

再結合は,マラリアの薬剤耐性の広がりを加速したり,阻害したりします. 新しいモデルでは,トリプルアルテミシニン併用療法 (ACT) が最強の遅延耐性を示し,次に複数のファーストライン療法 (MFT) が続く.

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