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Updated: Sep 10, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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BRCA2-欠乏性粒細胞の原始体および髄芽細胞腫における脆弱性の源としてのG四重複体

Danielle L Keahi1, Mathijs A Sanders2,3, Matthew R Paul4

  • 1Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065.

Proceedings of the National Academy of Sciences of the United States of America
|August 25, 2025
PubMed
まとめ

小脳細胞におけるBRCA2欠乏は,G四重複のDNAの不安定性を引き起こすことで,髄芽細胞腫を引き起こす. 腫瘍におけるPIF1ヘリケーゼのアップレギュレーションは,これらの脳腫瘍の治療標的として示唆しています.

キーワード:
BRCA2 についてG四重複体PIF1 について粒状細胞の祖先骨髄芽細胞腫

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