人間の腸に生息する細菌とキノコの共同代謝

Haley Gause¹, Alexander D Johnson^1,2

¹TETRAD Graduate Program, Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.

Proceedings of the National Academy of Sciences of the United States of America

|August 25, 2025

まとめ

菌類Candida albicansとバクテリアEnterococcus faecalisは腸内で代謝する. C.アルビカンスによるシトラートとホルマートの解毒は,両方の微生物の成長を促進します.

科学分野:

微生物学
微生物生態学
システム生物学

背景:

Candida albicansとEnterococcus faecalisはヒトの腸内微生物群の重要なメンバーである
腸の生態系の動態を解読するには種間の相互作用を理解することが重要です

研究の目的:

共同培養中のC. albicansとE. faecalisの転写反応と代謝相互作用を調査する.
腸内環境で共存するメカニズムの解明です

主な方法:

二重RNA配列解析は,単一栽培と共同栽培の両種の遺伝子発現をプロファイルするために使用されました.
実験はインビトロとグノトビオティックマウス腸モデルで行われた.
機能分析により,シトラートの交配と甲酸塩の解毒作用が確認された.

主要な成果:

共同培養はC. albicansとE. faecalisの両方において有意な転写変化を引き起こした.
シトラ酸代謝遺伝子は上調され,C. albicansはシトラ酸を生産し,E. faecalisはそれを利用し,E. faecalisの成長を促進した.
C. albicansは,E. faecalisによって生成される有毒なフォーマットの解毒を可能にし,成長の利点を授与しました.

結論:

シトラートとホルマートの解毒を伴う代謝サイクルにより,C. albicansとE. faecalisの共生が促進される.
これらの発見は,腸内微生物群の構造化における代謝相互作用の重要性を強調しています.
腸内の新種の代謝共生を明らかにした

キーワード:

カンジダ・アルビカンエントロコッカス・フェカリス RNA-seq について腸内微生物群

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