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Updated: Sep 10, 2025

07:51
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
193
高濃度デルタ-9-テトラヒドロカンナビノールの大麻製品と精神保健の成果:体系的なレビュー
Thanitsara Rittiphairoj1, Louis Leslie2, Jean-Pierre Oberste2
1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (T.R.).
Annals of internal medicine
|August 25, 2025
まとめ
高濃度のデルタ9テトラヒドロカンナビノール (THC) 製品は,特に精神病や大麻使用障害などの精神的健康への悪影響と関連しています. 不安やうつ病の治療に 役立つ可能性があるという証拠もありますが 矛盾しています
科学分野:
- 大麻の研究
- メンタルヘルス科学
- 薬理学について
背景:
- 大麻市場では,高濃度のデルタ9テトラヒドロカンナビノール (THC) 製品が増加しています.
- これらの強力な薬の メンタルヘルスへの影響を理解することは 極めて重要です
研究 の 目的:
- 高濃度THCカンナビス製品と精神疾患との関連に関する科学文献を体系的に検討する.
- 精神病,不安,うつ病,大麻使用障害 (CUD) に関する証拠をまとめること.
主な方法:
- 複数のデータベースを介して包括的な文献検索が行われました.
- 高濃度THCを1食分の5mgまたは10%以上または製品タイプ (例えば"シャッター"",ダブ") で定義した試験は含まれていた.
- 評価されたアウトカムには,不安,うつ,精神病/統合失調症,CUDが含まれ,結果は関連性および研究タイプによって分類されました.
主要な成果:
- 22万1000人以上の参加者を含む99件の研究が分析され,ほとんどの研究でバイアスのリスクは中等から高かった.
- 非治療的な研究では,高濃度のTHCと精神病/統合失調症 (70%) とCUD (75%) の間の不良な関連が一貫して示されました.
- 不安やうつ病に対する高THC製品の治療効果に関する証拠は低品質で不一致で,いくつかの研究では不利な関連が報告されました.
結論:
- 高濃度のTHC製品は,特に精神病とCUDなどの不良な精神的健康結果と関連しています.
- 不安とうつ病に対する潜在的な治療効果は,低品質で矛盾する証拠のためにさらなる調査を必要とします.
- 限界には研究バイアスと現代の大麻製品を評価する必要性があります.
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