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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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LncRNA SNHG15スポンジ miR-3143/FOXO3 ベンゼン暴露によって誘発される卵巣機能障害におけるオートファギーを調節する

Zhongming Ye1, Qihao Huang1, Haipeng Wu1

  • 1Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, 523808, China.

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まとめ

ベンゼンの曝露は卵巣細胞の過剰なオートファギーを引き起こし,機能障害を引き起こします. lncRNA SNHG15は重要な役割を果たし,ベンゼン誘発性生殖障害に対する潜在的な治療標的を提供します.

キーワード:
オートファジーベンゼンLncRNA について卵巣SNHG15

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科学分野:

  • 生殖毒学
  • 分子生物学
  • 細胞の自己消化

背景:

  • ベンゾンは発がん性物質で 生殖機能に問題があり 月経の異常などに繋がっています
  • 卵巣機能に対するベンゼンの影響の分子メカニズムは完全に理解されていません.
  • オートファギーの調節不全は様々な細胞機能障害に 関わっている.

研究 の 目的:

  • ベンゼン誘発性卵巣機能障害の 分子メカニズムを調査する
  • ベンゼン毒性におけるオートファギーと lncRNA SNHG15の役割を評価する.
  • ベンゼンの生殖効果を緩和する 潜在的な治療標的を特定する

主な方法:

  • ネズミの動的吸入による慢性ベンゼン曝露モデルを確立した.
  • qPCR,ウエスタン・ブロット,TEMを用いてマウスおよびヒトの卵巣粒細胞における自閉性のレベルを評価した.
  • SNHG15/miR-3143/FOXO3軸のベンゼン誘発の自己死における役割を調査した.

主要な成果:

  • ベンゼンの曝露はオートファギー,粒状細胞喪失,卵巣機能不全を誘発した.
  • ベンゼンはヒト卵巣の花粉細胞におけるSNHG15の発現を上位に調節した.
  • SNHG15は miR- 3143 / FOXO3軸経由でオートファギーを促進し,卵巣機能を低下させた.

結論:

  • ベンゼンとその代謝産物であるベンゾキノンは,卵巣の粒状細胞に過剰なオートファギーを誘発する.
  • SNHG15/miR-3143/FOXO3 ceRNA軸は,ベンゼン誘発性卵巣毒性の重要な媒介である.
  • SNHG15軸をターゲットにすることで,ベンゼンによる生殖障害に対する潜在的な治療戦略が提供されます.