関連する実験動画

Updated: May 5, 2026

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
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An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

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SpyTag-PEGylated プロバイオティクスは,IL-1Raを投与し,腸肺のクロストラックを調節し,セプティック肺損傷を軽減する

Qianyi Yao1, Tao Liu2, Jingtao Wen3

  • 1Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China.

Journal of controlled release : official journal of the Controlled Release Society
|August 25, 2025
PubMed
まとめ

経口投与された人工E. coliプロバイオティクスは,腸肺軸を調節することによって,結血症による肺損傷を軽減します. この新しいアプローチは 腸壁の整合性を高め 潜在的臨床使用のための全身の炎症を軽減します

キーワード:
IL-1Ra について外膜の膀,ピロプトーシスPEGylation ペグライレーションSpyCatcher-SpyTag システム

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Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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