ロペラミド誘発性消化不良のラットにおける胃腸機能と腸内微生物群の調節のための2つのハーブ製の薬剤の比較評価
Saeid Khakisahneh1, Jing-Hua Wang1, Xue-Ying Zhang2,3
1Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa-dong, Ilsandong-gu, Goyang-si, 10326, Republic of Korea.
Scientific reports
|August 25, 2025
まとめ
Shihosogan- tang (SST) は,腸内ホルモンを調節し,炎症を軽減し,腸内微生物群を調節することによって,Yijung- tang (YJT) よりもロペラミド誘発の消化不良を効果的に治療します. 両方とも腸内微生物の組成を変えました
科学分野:
- 胃腸内科
- 薬理学について
- 薬草 医学 研究
背景:
- 消化不良は 治療の選択肢が限られている 治療が難しい 病状です
- 薬草は胃腸疾患の治療の可能性を示しており,さらなる証拠が必要である.
研究 の 目的:
- ラットにおけるロペラミド誘発性消化不良の治療におけるShihosogan- tang (SST) とYijung- tang (YJT) の有効性を比較する.
- SSTとYJTの作用のメカニズムを調査する.
主な方法:
- ロペラミド (LOP) を用いてラットモデルでの消化不良を誘導した.
- ネズミはSST,YJT,またはモサプリド (陽性対照群) で治療された.
- 腸内パラメータ,血清グリリン,遺伝子発現,腸内微生物群への影響が分析された.
主要な成果:
- YJTとは異なり,SSTは腸の長さ,トランジット比,グリリンレベルを大幅に改善しました.
- YJTはSSTよりも 排泄とイレウムの形状を高めました
- SSTとYJTは,運動性,炎症,水吸収に関連する十二指管遺伝子発現を調節した.
- SSTとYJTは腸内微生物のベータ多様性を変化させたが,モサプリドはそうしなかった.
結論:
- ロペラミドによる消化不良を緩和する効果は,YJTよりも優れている.
- 潜在的メカニズムには腸内ホルモンの調節,炎症,腸内微生物群が含まれます.
- 消化不良に対するハーブ・フォーミュラメカニズムに関するさらなる研究が必要である.
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