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Updated: Apr 12, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
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iPSC ベースの in vitro モデルは,ヒトの胸膜上皮細胞の発達と複数の系統の特異性を再現します

Yann Pretemer1, Yuxian Gao1,2, Kaho Kanai1,3

  • 1Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

Nature communications
|August 25, 2025
PubMed
まとめ

研究者らは,ヒト誘発性多能幹細胞 (iPSC) モデルを開発した. このモデルは,T細胞開発研究と先天性T細胞疾患の潜在的な治療を助けるために,インビトロで多様な胸膜上皮細胞 (TEC) 系統を生成します.

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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