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Updated: Apr 9, 2026

Detection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry
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Detection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry

Published on: March 23, 2020

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ATE1ベースのアルギニレーションプロファイリングのための公正なプロテオミックプラットフォーム

Zongtao Lin1, Yixuan Xie2, Joanna Gongora2

  • 1Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO, USA. zongtao@wustl.edu.

Nature chemical biology
|August 25, 2025
PubMed
まとめ

タンパク質のアルギニル化部位を 発見する新しい方法を開発しました 翻訳後の変異は難しいものです このプラットフォームは,より広範な生物学的洞察のための以前の技術の限界を克服し,真のアルギニレーションを特定します.

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ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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