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Updated: Sep 10, 2025

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

Published on: May 2, 2019

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ミトコンドリアでコードされたペプチドMOTS-cは,糖尿病を遅らせるために臓小島細胞の老化を防ぐ

Byung Soo Kong1,2,3, Hyunsuk Lee4,5, Sehi L'Yi6

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. bkong@hsph.harvard.edu.

Experimental & molecular medicine
|August 25, 2025
PubMed
まとめ

ミトコンドリアペプチドMOTS-cのレベルは,老化と糖尿病とともに低下し,臓小島細胞の老化に寄与する. MOTS-c治療は老化を逆転させ,グルコース不耐性を改善し,糖尿病の老化治療薬としての可能性を示唆した.

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