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Updated: Sep 10, 2025

CD Spectroscopy to Study DNA-Protein Interactions
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DNAの屈曲性は,トランスクリプション因子の核細胞への結合を調節する.

Luca Mariani1, Xiao Liu2,3,4, Kwangwoon Lee2,5,6

  • 1Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. lmariani@bwh.harvard.edu.

Nature structural & molecular biology
|August 25, 2025
PubMed
まとめ

先駆的な転写因子 (TFs) はDNAを結合することで 細胞の運命を制御します PIONEAR-seqという新しい方法は,TFモチーフだけでなく,核細胞配列の文脈が,この重要なパイオニア結合を調節することを明らかにしています.

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