重度の高カルセミアにより,多発性骨損傷による分散型大B細胞リンパ腫の場合には,緊急の血液透析と多剤療法が必要である

Yusaku Watanabe¹, Shohei Kaneko^2,3, Rinka Yamamoto¹

¹Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

BMC nephrology

|August 25, 2025

まとめ

骨の損傷を伴う拡散性B細胞リンパ腫 (DLBCL) の希少な合併症である重度の高カルセミアは,成功裏に管理されました. 治療には血液透析,水分補給,デノスマブを含む多剤療法があり,持続的なカルシウムレベル制御を達成しました.

科学分野:

腫瘍学
血液学
腎臓科

背景:

重度の高カルセミアは,多発性骨損傷を含む拡散性大B細胞リンパ腫 (DLBCL) の患者における希少だが深刻な合併症である.
この生命を脅かす状態には確立された標準的な治療法はありません

研究の目的:

多発性骨損傷によるDLBCLによる重度の高カルセミアの報告
この状態の成功管理について説明します.

主な方法:

重度の高カルセミア (23. 0 mg/ dL) を有する54歳の女性患者は,緊急の血液透析,水分補給,カルシトニン,ビスホスフォネート,デノスマブで治療を受けた.
DLBCLの診断は骨生検と骨髄抽出で確認された.
DLBCLのために化学療法を開始しました.

主要な成果:

最初の治療は一時的な改善のみであり,血清カルシウム濃度は回復した.
デノスマブ投与は,血清カルシウム濃度の有意な低下と持続的なコントロールをもたらした.
血清カルシウム濃度は,化学療法開始後の追跡期間中に安定した.

結論:

この症例では重度の高カルセミアが多発性骨損傷によるDLBCLに起因した.
緊急ヘモダイアリス,積極的な水分補給,カルシトニン,ビスホスフォネート,デノスマブを併用して治療が成功しました.
化学療法により,カルシウム濃度の安定が維持されました.

キーワード:

デノスマブ拡散型大B細胞リンパ腫ヘモダイアリス高カルセミア

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